Endocrine Abstracts

Introduction: Fear of illness and quality of life have been proven to be affected in women with osteoporosis. Osteoporosis causes an increase in morbidity and mortality but the direct ways by which it affects fear of illness and quality of life are not yet known. The present study aims to assess the fear of illness and quality of life (QoL) as well as their correlation with bone density and age in a Greek rural population of postmenopausal women with osteoporosis.<p class=...

Background: Conflicting results regarding adiponectin levels in women with polycystic ovary syndrome (PCOS) have been reported. To evaluate adiponectin levels in PCOS, a systematic review of all studies comparing adiponectin levels in women with PCOS to healthy controls and a meta-analysis of those involving women with similar Body Mass Index (BMI) were performed. Influence of possible effect modifiers, such as insulin resistance (IR) and testosterone, was investigated. Influe...

Introduction: Type 2 diabetes mellitus (T2DM) and osteoporosis may co-exist in the same individual. However, the exact effect of anti-osteoporotic treatment on glucose metabolism is unknown. We aimed to systematically review the effects of anti-osteoporotic medications on glucose metabolism and the incidence of T2DM.Methods/design: PubMed, Cochrane and EMBASE were systematically searched until the 31 of December, 2017.Results: ...

Introduction: Early menopause (defined as age of menopause <45 years) and premature ovarian failure (defined as age of menopause <40 years) are associated with accelerated bone loss and increased risk of osteoporosis in later life. However, their association with increased fracture risk has not been established, with studies yielding conflicting results. The aim of this study was to systematically review and meta-analyze studies evaluating the effect of age at onset of...

ObjectiveThe exact risk of type 2 diabetes in women with polycystic ovary syndrome (PCOS) is unknown. It is also unclear if obesity independently increases the risk in this population. The aim of this study was to systematically review and synthesize the best available evidence regarding the association between PCOS and type 2 diabetes, stratified according to obesity status.MethodsA comprehensive search was ...

PurposeRadioactive iodine (RAI) is frequently used as adjuvant therapy in patients with differentiated thyroid cancer (DTC). However, its effect on ovarian reserve has not been fully elucidated, with studies yielding inconsistent results. The aim of this study was to systematically review and meta-analyze the best available evidence regarding the effect of RAI on ovarian reserve in premenopausal women with DTC.Methods<p class="...

ContextWhether pre-operative vitamin D deficiency (VDD) contributes to post-operative hypoparathyroidism (hypoPT) risk is unknown.ObjectiveTo meta-analyze the best available evidence regarding the association between pre-operative vitamin D status and hypoPT risk.Data SourcesA comprehensive literature search was conducted in PubMed, CENTRAL and Scopus databases, u...

Objective: Menopausal hormone therapy (MHT) is efficacious in reducing the risk of vertebral, non-vertebral and hip fractures, irrespective of age, falls risk or baseline FRAX probability. However, the optimal sequential anti-osteoporotic treatment after MHT discontinuation has not yet been designated. This systematic review aimed to obtain the best evidence regarding the effect of antiresorptive or osteoanabolic treatment on bone mineral density (BMD) and/or fracture risk fol...

Aim: To investigate reproductive function disorders in young women with type 1 diabetes mellitus (T1DM).Patients and methods: We studied 53 women with T1DM (duration 8.0±5.6 y) and 51 healthy controls with normal menstrual cycles and no clinical hyperandrogenism, matched for age (19.4±4.3 vs 20.8±3.1 years, P=0.063) and body mass index (BMI) (22.2±2.7 vs 21.4±1.9 kg/m2, P=0.088). T1DM (insulin regimen...

Objective: Menopausal transition has been associated with an increased risk of cardiovascular disease (CVD), mainly attributed to atherogenic dyslipidaemia, central obesity and insulin resistance. Whether arterial hypertension (AH) also contributes to menopause-associated CVD is currently unknown. The aim of this study was to systematically investigate and meta-analyze the best available evidence regarding the association between early menopause (EM) and AH risk.<p class="...